D-Worm Syrup

COMPOSITION:
Each 5 ml contains
albendazole B.P. 200mg

DESCRIPTION:
It has the advantage of single dose administration in many causes like ascaries, hookworm (both species) and enterobiasis.

MECHANISM OF ACTION:
D-Worm contains Albendazole which has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific. This action may be considered secondary to the effect on the mmircotubules due to the deceased absorption of glucose. This action occurs in the presence of reduced amounts of nicotinamide-adenine dinucleotide in reduced from (NADH), which is a coenzyme involved in many cellular oxidation-reduction reactions.
albendazole has larvicidal effects in necatoriasis and ovicidal effects in ascariasis, ancyclostomiasis and trichuriasis.

PHARMACOKNETICS:

D-worm is poorly absorbed from G.I. tract, but rapidly undergoes extensive first-pass metabolism. The principal metabolite albendazole sulfoxide has anthelmintic activity and a plasma half-life of about 8.5 hours.

INDICATION:
Single or mixed-instestinal worm infestation caused by Nematodes-Round-worm, hook-worm, Thread-warm, strongloids, ship-worm, Cestodes-Tape-worms (Hydatid disease, Cysticercosis).

SHAKE WELL BEFORE USE.

DOSAGE AND ADMINISTRATION:
Over 2 years, 10 ml single dose, or as directed by the physician. Not recommended in pregnancy.

CONTRAINDICATIONS:
Hypersensitivity to the benzimidazole class of compounds.

DRUG INTERACTIONS:
Antidiabetic agents potentiates their action, H2 antagonists increase the plasma concentration of albendazole.

SIDE-EFFECTS: G.I. disorders.

SPECIAL PRECAUTIONS:
Patients with hepatic or renal disease. In woman of child bearing age administer within 7 days of start of normal menstruation.

Paediatrics:
Contraindicated in children below 1 year.

STORAGE:
Keep away from heat 7 light.
PRESENTATION:
10 ml in Glass bottle with Duplex board carton.