Main Line: (256) 414 250830
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Location: Plot # 51/2 Kampala Rd
  • Description

    Each film coated tablet contains:
    Azithromycin USP 500mg
    (As Azithromycin Dihydrate USP)
    Colour: Titanium Dioxide

    Azzy tablet contains the active ingredient Azithromycin, an azalide, a subclass of macrolide antibiotics for oral administration. It is derived from Erythromycin, however it differs chemically from Erythromycin in that a methyl substituted Nitrogen atom is incorporated into the lactone ring.

  • Mechanism Of Action:

    It acts by binding to the 50S ribosomal subunit of susceptible microorganisms and, thus, interfering with microbial protein synthesis. Nucleic Acid synthesis is not affected.

  • Pharmacokinetics & Indications:

    Following oral administration about 40% of a dose of Arzithromycin is bioavailable. Absorption from the capsule formulation, but not the tablet formulation is reduced to food. Peak plasma concentrations are achieved 2;3 hours after a dose, but Azithromycin extensively distributed to the tissue, and tissue concentrations sequentially remain much higher than those in the blood, in contrast to most other antibacterial, plasma concentrations are therefore of little value as a guide of efficacy. High concentrations are taken up into white blood cells. There is little diffusion into the CSF when the meninges are not inflamed. Small amounts of Azithromycycin are detethylated in the liver, and it is excreted in bile as unchanged drug and metabolities. About 6% of oral dose is excreted in the urine. The terminal examination half life is probably in excess of 40hours.

    Azithromycin is indicated for infections caused by susceptide organisms, in lower respiratory tract infections including bronchitis and pneumonia, in skin and soft tissue infections, in acute otitis media and in upper respiratory, tract infections including sinusitis and pharyngitis / tonsilitis (Pencicillin is the usual drug of choice in the treatment of Streptococcus pyogenes pharyngitis, including the prohylaxis of rheumatic fever. Azithromycin is generally effective in the eradication of streptocci from the oropharynyx, however data establishing the efficacy of azithromycin and the subsequent prevention of rheumatic fever are not available at present)
    In sexual transmitted diseases in men and women, azithromycin is indicated in the treatment of uncomplicated genital infections due to chlamydia trachomatis. It is also indicated in the treated of cancroid due to Harmophilus ducreyi and uncomplicated genital infection due to non-multiresistant Neisseria gornorrhoea; concurrent infection with Treponerma pallidum should be excluded.AZithromycan is indicated either alone or in combination with rifabutin for prophylaxis against Mycobacterium avium-intracellulare complex (MAC) infection, an opportunistic infection prevention in patients with advanced human immunodefieciency virus(HIV).
    Azithromycin is indicated in combination with ethambutol for the treatment of disseminated MAC(DMAC) infection in patients with advanced HIV infection.

  • Dosage

    As directed by the physician.

  • Contraindications:

    The use of this product is contraindicated in patients with hypersensitivity to Azithromycin, any macrolide or ketolide antibiotic.

  • Precautions:

    Azithromycin tablets can be taken with or without food. Patients should also be cautioned not to take Aluminiun and Magnesium containing antiacids and Azithromycin simultaneously. The patients should be directed to discontinue Azithromycin immediately and contact a physician if any signs of an allergic reaction occur.

  • Storage

    Store in cool & dry place