Actipar Syrup

Each ml contains:
Each 5ml contains:
Piperazine Citrate U.S.P.
Equivalent to Piperazine hexahydrate 500mg.
In a Flavoured syrup base.
colours: Tartrazine & Sunset Yellow FCF

DESCRIPTION: Actipar syrup contains Piperazine citrate, which is an anthelminntic.

MECHANISM OF ACTION:

Piperazine blocks the reponse of the worm muscle to acetylcholine, presumably by causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. while the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Rapidly absorbed from the gastrointestinal tract. Approximately 25% is metabolized in the liver. Piperazine is nitrosated to form N-mononitrosopiperazine (MNPz) in gastric juice and further metabolized to N-nitroso-3-hydroxypyrrolidine. Renal-Approximately 20% is excreted unchanged in the urine with 24 hours.

Ascariasis or Enterobiasis (treatment)-Piperazine is indicated as alternative treatement for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). Piperazine is especially useful in the treatment of partial intestinal obstruction caused by Ascaris worm, which is a condition primarily seen in children.

Children over 12yr of age: 6 teaspoonful(30ml)
Children 6 to 12 years : 4 teaspoonful (20ml)
Children 5 to 6 years: 3 teaspoonful (15ml)
Children 2 to 4 years: 2 teaspoonful (10ml)
Children under 2 years: 120mg per kg body wt

Hypersensitivity reactions to piperazine and its salt.

Regular visits to physician to check progress checking with physician if no improvement after the full course of treatment or if symptoms persist.

DRUG INTERACTION:
Phenothiazines, high doses of piperazine may enhance the effects of phenothiazines, such as chlorpromazine, and increase the risk of seizures; concurrent use is not recommended. Pyrantel may antagonize the anthelmintic effects; concurrent is not recommended.

SIDE EFFECTS: Blurring of vision(in rare case)
hypersensitivity (fever; joint pain; skin rash or itching )

Store below 40°c.(104°F), preferably between 15 and 30°c (59 and 86°F), in a well-closed container,

Keep out of reach of children.

Presentation:
30ml in Glass in Duplex Board carton.